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Invitrogen™ POT1 Polyclonal Antibody
Description
Recommended positive controls: 293T, A431, Jurkat. Predicted reactivity: Pig (85%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
POT1 is a component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. It is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Pot1 also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. It binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Its activity is TERT dependent but it does not increase TERT activity.
Spécification
Spécification
| Antigène | POT1 |
| Applications | Western Blot |
| Classification | Polyclonal |
| Concentration | 0.73 mg/mL |
| Conjugué | Unconjugated |
| Formule | 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 |
| Expression | POT1 |
| Numéro d’ordre du gène | Q9NUX5 |
| Alias de gène | 1500031H18Rik; AI505244; AI851169; CMM10; DKFZp586D211; Dolichyl-phosphate-mannose--protein mannosyltransferase 1; GLM9; HPOT1; mPot1; Pomt1; POT 1; POT1; POT-1; Pot1a; POT1-like telomere end-binding protein; protection of telomeres 1; protection of telomeres 1 homolog; protection of telomeres 1A; protection of telomeres protein 1; protein O-mannosyltransferase 1; Protein O-mannosyl-transferase 1; protein-O-mannosyltransferase 1 |
| Symboles de gène(s) | POT1 |
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Nom du produit
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