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MAP3K5 (phospho S966), Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™
Description
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq
Spécification
Spécification
| Antigène | MAP3K5 |
| Applications | Immunohistochemistry (PFA fixed), Western Blot |
| Classification | Polyclonal |
| Conjugué | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic phosphopeptide of MAP3K5. |
| Dilution | Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:100) The optimal working dilution should be determined by the end user. |
| Formule | In PBS (without Mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide) |
| Expression | MAP3K5 |
| Alias de gène | ASK1/MAPKKK5/MEKK5 |
| Symboles de gène(s) | MAP3K5 |
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For Research Use Only
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