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  6. Invitrogen™ Snail1 Monoclonal Antibody (20C8), eBioscience™, Invitrogen™

Invitrogen™ Snail1 Monoclonal Antibody (20C8), eBioscience™, Invitrogen™

Code produit 15537696
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10 mg
2 mg
25 μg
Conditionnement:
10mg
25µg
2mg
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Code produit Quantité unitSize
15537696 25 μg 25µg
17110812 2 mg 2mg
17120812 10 mg 10mg
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Code produit 15537696 Fournisseur Invitrogen™ Code fournisseur 14985980

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Description

Mouse Monoclonal Antibody

The MAb 20C8 recognizes human Snail1, a 29 kDa zinc finger transcription factor. Snail1 and Slug both belong to a family of transcription factors that are responsible for inducing epithelial to mesenchymal transition (EMT) during normal organ development and tumor progression. Snail1 expression is localized to both the cytoplasm and nucleus and functions as a transcriptional repressor of E-cadherin, claudins, occludin, and desmoplakin. During embryonic development, Snail1 is localized to the mesoderm, while in the adult, expression is inducible and is usually limited to activated fibroblasts and some mesenchymal cells. Overexpression of Snail1 has been found in carcinomas and fibrosarcomas and may be used as an early marker for EMT.

Zinc finger protein SNAI1 (SNAIL)is a zinc finger transcriptional repressor which down regulates the expression of the ectodermal gene within the mesoderm and functions to form the mesoderm and neural crest. It is reported that SNAI1 acts as an important factor of tumor invasion as evidenced by its role in E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, the expression of SNAI1 and/or the homologous SNAI2 (Slug) has been associated with E-cadherin repression, local or distant metastasis, tumor recurrence, or poor prognosis in different tumor series. It is also reported that Snail 1 protein in the stromamay be anew putative prognosis marker for colon tumors.
TRUSTED_SUSTAINABILITY

Spécification

Antigène Snail1
Applications ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 20C8
Concentration 0.5 mg/mL
Conjugué Unconjugated
Formule PBS with 0.09% sodium azide; pH 7.2
Expression Snai1
Numéro d’ordre du gène O95863
Alias de gène AI194338; dJ710H13.1; Protein sna; protein snail homolog 1; SLUGH2; SNA; Sna protein; Sna1; SNAH; snai; SNAI1; Snail; snail 1; snail 1 homolog; snail 1 zinc finger protein; snail 1, zinc finger protein; snail family transcriptional repressor 1; snail family zinc finger 1; snail homolog 1; Snail1; Zinc finger protein SNAI1
Symboles de gène(s) Snai1
Espèces hôtes Mouse
Méthode de purification Affinity chromatography
Quantité 25 μg
État réglementaire RUO
Primaire ou secondaire Primary
Identification génétique (Entrez) 6615
Espèces cibles Human
Contenu et stockage 4°C
Type de produit Antibody
Forme Liquid
Isotype IgG2a κ
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