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Invitrogen™ SP1 Polyclonal Antibody

Description
Recommended positive controls: 293T, K562, THP-1, HL-60, Raji. Predicted reactivity: Mouse (96%), Rat (99%), Rhesus Monkey (99%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.
Spécification
Spécification
| Antigène | SP1 |
| Applications | ChIP Assay, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry |
| Classification | Polyclonal |
| Concentration | 0.88 mg/mL |
| Conjugué | Unconjugated |
| Formule | PBS with 20% glycerol and 0.025% ProClin 300; pH 7 |
| Expression | SP1 |
| Numéro d’ordre du gène | P08047 |
| Alias de gène | 1110003E12Rik; AA450830; AI845540; HGNC:11205; SP1; Sp1 transcription factor; Sp1-1; specificity protein 1; trans-acting transcription factor 1; transcription factor Sp1; TSFP1 |
| Symboles de gène(s) | SP1 |
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Nom du produit
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