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Invitrogen™ TDG Polyclonal Antibody

Description
Recommended positive controls: HeLa, Jurkat, Raji, NCI-H929, TDG-transfected 293T. Predicted reactivity: Human (99%), Mouse (88%), Rat (87%), Bovine (91%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mis paired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
Spécification
Spécification
| Antigène | TDG |
| Applications | Western Blot, Immunocytochemistry |
| Classification | Polyclonal |
| Concentration | 1 mg/mL |
| Conjugué | Unconjugated |
| Formule | PBS with 20% glycerol and 0.01% thimerosal; pH 7 |
| Expression | TDG |
| Numéro d’ordre du gène | P56581, Q13569 |
| Alias de gène | C-JUN leucine zipper interactive protein JZA-3; E130317C12Rik; G/T mismatch-specific thymine DNA glycosylase; hTDG; Jza1; JZA-3; Tdg; thymine DNA glycosylase; thymine-DNA glycosylase |
| Symboles de gène(s) | TDG |
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Nom du produit
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