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Invitrogen™ ZO-1 Monoclonal Antibody (ZO1-1A12), Alexa Fluor™ 647

Product Code. 15648028
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Quantité:
50 μL
Unit Size:
50µL
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15648028 50 μL 50µL
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Product Code. 15648028 Supplier Invitrogen™ Supplier No. MA339100A647

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357.20 EUR valable jusqu'au 2026-03-27
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Description

Mouse Monoclonal Antibody

ZO-1 Monoclonal Antibody for ICC/IF

ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigène ZO-1
Applications Immunocytochemistry
Classification Monoclonal
Clone ZO1-1A12
Concentration 1 mg/mL
Conjugué Alexa Fluor 647
Formule PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
Expression TJP1
Numéro d’ordre du gène O97758, Q07157
Alias de gène DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1
Symboles de gène(s) TJP1
Espèces hôtes Mouse
Immunogène Human recombinant ZO-1 fusion protein encompassing amino acids 334-634.
Méthode de purification Affinity chromatography
Quantité 50 μL
État réglementaire RUO
Primaire ou secondaire Primary
Identification génétique (Entrez) 403752, 7082
Espèces cibles Canine, Human
Contenu et stockage 4°C, store in dark, DO NOT FREEZE!
Type de produit Antibody
Forme Liquid
Isotype IgG1
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