Invitrogen™ ACE Polyclonal Antibody

Description

Immunogen sequence: LHQCDIYRST KAGAKLRKVL QAGSSRPWQE VLKDMVGLDA LDAQPLLKYF QPVTQWLQEQ NQQNGEVLGW PEYQWHPPLP DNYPEGIDLV TDEAEASKFV EEYDRTSQVV WNEYAEANWN YNTNITTETS KILLQKNMQI ANHTLKYGTQ ARKFDVNQLQ NTTIKRIIKK VQDLERAALP AQELEEYNKI LLDMETTYSV ATVCH Positive Samples: HepG2, MCF7, Mouse lung; Cellular Location: Cell membrane, Cytoplasm, Single-pass type I membrane protein.

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes-the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.