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  6. Annexin II (Lipocortin II, Calpactin I) Mouse anti-Human, FITC, Clone: 5, BD

Annexin II (Lipocortin II, Calpactin I) Mouse anti-Human, FITC, Clone: 5, BD

Mouse Monoclonal Antibody

449.00€ - 738.55€

Specifications

Antigène Annexin II (Lipocortin II, Calpactin I)
Clone 5
Concentration 250μg/mL
Applications Immunofluorescence
Classification Monoclonal
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BD Biosciences
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BD Biosciences
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Description

Description

Annexin II (p36), originally discovered as a substrate for the src oncogene, is one of the most studied members of the annexin family of calcium-dependent phospholipid-binding proteins. It exists in cells as either a monomer or a heterotetramer complexed with p11, an S100-related protein. In vitro, it has been found that unphosphorylated annexin II is capable of causing aggregation of chromaffin granules, and, upon phosphorylation, induces fusion of the granules' membranes. A similiar phenomenon may occur in the final steps of exocytosis after cytoplasmic annexin translocates to the subplasmalemmal region and is phosphorylated by protein kinase C. However, other studies refute annexin II's involvement in exocytosis, and a conclusive role for annexin II in membrane trafficking remains debated.

Host Species: Mouse
Clone: 5
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human Annein II aa. 123-328

Immunofluorescence, Immunoprecipitation

Specifications

Specifications

Annexin II (Lipocortin II, Calpactin I)
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
Lipocortin II, Calpactin I
5
Immunofluorescence
FITC
RUO
Human
Human Annein II aa. 123-328
Primary
Store undiluted at -20°C.
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