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CD154 Mouse anti-Human, FITC, Clone: TRAP1, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 555699

Informations supplémentaires : Poids : 0.10000kg

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Code produit. 10081934

  • 421.80€ / 1 pièce
Expédition estimée: 02-01-2023
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Description

Description

The TRAP1 monoclonal antibody specifically binds to CD154. CD154 is a 39 kDa type II membrane glycoprotein that is a member of the tumor necrosis factor superfamily, Tumor necrosis factor ligand superfamily member 5 (TNFSF5). CD154 is expressed on a variety of cell types including activated CD4+ T cells and some CD8+ T cells, NK cells, mast cells and basophils. CD154 is also known as CD40 ligand (CD40L); it serves as a ligand for CD40 that is expressed on B cells, macrophages, and dendritic cells. The expression of CD154 by activated T-helper cells costimulates B-cell activation and proliferation through binding to CD40 expressed on B cells. In response to T-dependent antigens, the CD154 and CD40 interaction is required for B-lymphocyte differentiation, including immunoglobulin production and isotype switching and memory B cell generation. The TRAP1 antibody can partially block T cell-B cell interaction and inhibit the subsequent proliferation, differentiation, and memory formation of B cells. It has been reported that patients with X-linked hyper-IgM syndrome have defective expression of functional CD154 due to mutations in the CD40LG gene that encodes CD154.

Spécification

Spécification

CD154
Monoclonal
FITC
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Affinity Purified
RUO
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry
TRAP1
CD40LG; CD40 ligand; CD40L; TNFSF5; T-BAM; TRAP
Mouse
100 Tests
Immunology
Rhesus Monkey, Human, Cynomolgus, Baboon
IgG1 κ
Vidéos
FDS
Documents

Documents

Certificats
Promotions

Promotions

For Research Use Only.