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DSIF Mouse, Unlabeled, Clone: 17, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 611107

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15855799

  • 543.78€ / 1 kit
Expédition estimée: 24-02-2023
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Description

Description

In living systems, the relative amounts of any protein are controlled at many levels. For example, amounts are affected by protein degradation, regulation of the translational rates of polypeptide synthesis (translational regulation), and control of the rates of mRNA synthesis (transcriptional regulation). Transcriptional regulation involves modulation of the rate-limiting enzyme RNA polymerase. DSIF (DRB sensitivity-inducing factor) is a heterodimeric transcription elongation protein. It is composed of a large subunit of 160kDa and a small subunit of 14kDa. These large and the small subunits are homologs of the yeast gene products Stp5 and Stp4, respectively. Spt4 and 5 are transcription factors which are critically important for the activity of RNA polymerase. In conjunction with DRB, DSIF attenuates RNA polymerase II elongation steps. However, in limiting amounts of ribonucleotides, DSIF, by itself, stimulates the elongation rate of RNA polymerase II. Thus, the identification of a human regulator for transcriptional elongation will greatly enhance our understanding of this critical step in mammalian gene expression.

Host Species: Mouse
Clone: 17
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human DSIF aa. 866-985
Formula Weight [Chemical]: 160kDa

Immunofluorescence, Western Blotting

Spécification

Spécification

DSIF
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Human DSIF aa. 866-985
150 μg
Cell Biology
Rat, Mouse, Human, Canine
IgG1
Western Blot
17
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Vidéos
FDS
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Documents

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For Research Use Only.