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Elk-1 (pS383) Mouse, Alexa Fluor 647, Clone: M21-1721, BD
Mouse Monoclonal Antibody
Marque: BD Biosciences 560413
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Description
Elk-1 is a 62kDa member of the Ets oncogene family of transcription factors and a member of the subfamily of ternary complex factors (TCF). Ets proteins mediate a variety of gene activities in response to serum and growth factors. Proteins in the TCF subfamily form a ternary complex by binding to the Serum Response Element (SRE) in conjunction with a dimer of Serum Response Factors (SRF). Elk-1 is phosphorylated by mitogen-activated protein (MAP) kinase pathways in vivo at a cluster of S/T motifs at its carboxy-terminus.
Phosphorylation at these sites, particularly at serine 383 (S383), is critical for Elk-1 transcriptional activation. Studies have shown that Elk-1 is a direct target of activated MAP kinase, and that it is also a target of the stress-activated kinase SAPK/JNK. The M21-1721 monoclonal antibody recognizes the phosphorylated S383 of activated Elk-1. The orthologous phosphorylation sites of mouse and rat Elk-1 are S384 and S382, respectively.
Host Species: Mouse
Clone: M21-1721
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Phosphorylated Human Elk-1 Peptide
Intracellular Staining
Spécification
| Elk-1 (pS383) | |
| Monoclonal | |
| Alexa Fluor 647 | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| Phosphorylated Human Elk-1 Peptide | |
| 50 Tests | |
| Cell Biology | |
| Human, Mouse, Rat | |
| IgG1 κ |
| Flow Cytometry | |
| M21-1721 | |
| ELK1 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
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