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Exportin-1 (CRM1) Mouse anti-Human, Unlabeled, Clone: 17, BD
Mouse Monoclonal Antibody
Marque: BD Biosciences 611832
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Description
The nuclear pore complex (NPC) is a 125MDa nuclear envelope complex that mediates nucleocytoplasmic shuttling of RNA and protein. NPC is comprised of more than 30 different proteins, including Ran/TC4, importins, and exportins . Exportin-1(hCRM1/XPO1) is the widely expressed human homologue of the yeast CRM1 protein, which functions in the maintenance of chromatin structure and nuclear export. Exportin-1 has an N-terminal CRIME domain that is homologous to yeast CRM1 and importin-β. Intracellular localization of Exportin-1 shows association with the NPC and overexpression of Exportin-1 in Xenopus oocytes stimulates Rev and U snRNA export from the nucleus. Exportin-1 also binds other nuclear transport related proteins, such as RanGTP, snurportin-1, and the nucleoporins CAN/Nup214 and Nup50. Overexpression of CAN leads to sequestration of Exportin-1 in the nucleoplasm, which inhibits cell growth and induces apoptosis. In addition, Exportin-1 may export specific proteins, such as Rev and PKI, via binding to a leucine-rich nuclear export signal (NES). Thus, Exportin-1 is an important protein and RNA nuclear export receptor, which may be required for normal cell growth and survival.
Host Species: Mouse
Clone: 17
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human hCRM1 aa. 2-122
Immunofluorescence, Western Blotting
Spécification
| Exportin-1 (CRM1) | |
| Monoclonal | |
| 250μg/mL | |
| CRM1 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at -20°C. |
| Western Blot | |
| 17 | |
| Unconjugated | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Human hCRM1 aa. 2-122 | |
| 50 μg | |
| Cell Biology | |
| Canine, Chicken, Human, Mouse, Rat | |
| IgG1 |
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Nom du produit
For Research Use Only.
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