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FAK (pY397) (Focal Adhesion Kinase (pY397)) Mouse anti-Human, Unlabeled, Clone: 18, BD
Mouse Monoclonal Antibody
452.00€ - 760.00€
Spécification
Antigène | FAK (pY397) (Focal Adhesion Kinase (pY397)) |
---|---|
Clone | 18 |
Concentration | 250μg/mL |
Applications | Western Blot |
Classification | Monoclonal |
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
---|---|---|---|---|---|---|---|---|---|
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
15846029
|
BD Biosciences
611806 |
50 μg |
452.00€
1 kit |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | |||||
15856029
|
BD Biosciences
611807 |
150 μg |
760.00€
1 kit |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | |||||
Description
Focal Adhesion Kinase (FAK) is a cytoplasmic tyrosine kinase that colocalizes with integrins in focal adhesions. This cellular localization is directed by a 125 amino acid sequence at the C-terminus called “Focal Adhesion Targeting” sequence (FAT). The binding of extracellular matrix ligands to integrins triggers autophosphorylation at Tyr-397, and activation of FAK through phosphorylation of Tyr residues (Tyr-576 and Tyr-577) in the kinase domain activation loop. For example, cell adhesion to a fibronectin substratum involves concurrent activation of Src and phosphorylation of the FAK activation loop. In addition, phosphorylation of other Tyr residues (Tyr-925 and Tyr-861) creates binding sites for SH2 domains of intracellular signaling molecules such as Src, PI3 kinase, and Grb2. FAK's ability to bind numerous structural and signaling proteins via a variety of interactions is important for FAK activation level and for FAK interaction with a variety of substrates localized to sites of cell adhesion. Thus, FAK activity is regulated by a complex set of phosphorylation sites, and this phospho-regulation could be important for cell motility, cell growth, cytoskeletal organization and adhesion-dependent cell survival.
Host Species: Mouse
Clone: 18
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human FAK (pY397)
Bioimaging, Immunofluorescence, Western Blotting
Spécification
FAK (pY397) (Focal Adhesion Kinase (pY397)) | |
250μg/mL | |
Monoclonal | |
Mouse | |
Cell Biology | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
IgG1 | |
Affinity Purified | |
Focal Adhesion Kinase (pY397) |
18 | |
Western Blot | |
Unconjugated | |
RUO | |
Human | |
Human FAK (pY397) | |
Primary | |
Store undiluted at -20°C. |
For Research Use Only.