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NKp46 Mouse anti-Human, Unlabeled, Clone: 9E2/NKP46, BD
Mouse Monoclonal Antibody
Marque: BD Biosciences 557847
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Description
NKp46, a major cytoxicity receptor of NK cells, is a type I membrane glycoprotein (46kDaa) is expressed on resting and activated NK cells. Its extracellular region contains two C2-type, Ig-like domains. The transmembrane domain contains a positively charged amino acid (Arg) which could be involved in stabilizing the association with CD3ζ. Its intracellular region does not contain immunoreceptor tyrosine-based activating motifs (ITAM), but it is linked to intracytoplasmic transduction machinery by its association with CD3ζ and FcεRIγ adaptor proteins. NKp46 along with NKp30 and NKp44 are referred to as natural cytoxicity receptors (NCR) and play a very important role in killing virus-infected, tumor cells and MHC-class I-unprotected cells. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.
Host Species: Mouse
Clone: 9E2
Isotype: IgG1 κ
Species Reactivity: Human
Flow Cytometry
Spécification
| NKp46 | |
| Monoclonal | |
| 1.0mg/mL | |
| No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay. | |
| Human NKp46 Recombinant Protein | |
| 0.5 mg | |
| Immunology | |
| Human | |
| IgG1 κ |
| Flow Cytometry | |
| 9E2/NKP46 | |
| Unconjugated | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C |
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Nom du produit
For Research Use Only.
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