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RORγt Mouse anti-Human, PE, Clone: Q21-559, BD
Description
The Q21-559 monoclonal antibody recognizes ROR gamma t (RORγt), an isoform of RORgamma (RORγ). RORγt is a DNA-binding transcription factor that is encoded by the RORC (RAR-related orphan receptor C) gene. It belongs to the ROR/RZR orphan nuclear receptor family. Two protein isoforms are produced from the RORC gene by alternative splicing: RORγγt is highly restricted to the thymus where it is expressed exclusively in immature CD4+CD8+ thymocytes and in peripheral Th17 and LTi cells. RORγt reportedly functions as an essential transcription factor for the development of secondary lymphoid tissues. It also plays an important regulatory role in thymopoiesis and effector T cell differentiation, especially for Th17 cells.
Spécification
Spécification
| Antigène | RORγt |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Clone | Q21-559 |
| Conjugué | PE |
| Description | RORgt; ROR gamma t; RORC; NR1F3; RORG; RZRG; TOR; RZR-GAMMA |
| Formule | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
| Espèces hôtes | Mouse |
| Immunogène | Human RORγt Recombinant Protein |
| Méthode de purification | Affinity Purified |
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