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BLVRA Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marque: Proteintech 10775-1-AP-150UL
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Description
Biliverdin reductase (BLVR) is a ubiquitously expressed, small cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. The first step of this process is catalyzed by heme oxygenase, an enzyme that converts heme to iron, carbon monoxide, and biliverdin. BLVR is unique among all enzymes to date in being dual pH/dual cofactor-dependent, as it requires NADH (pH 6. 7) or NADPH (pH 8. 7) as an electron donor. There are two isoforms of BLVR, biliverdin-IX alpha-reductase (BLVRA), the major component of human adult liver, and biliverdin-IX beta-reductase (BLVRB), found predomitly in fetal liver. The product of BLVR, bilirubin, is an important biological antioxidant, however it is also a neurotoxin and the cause of kernicterus. In addition to being an antioxidant, it inhibits kinase activity and the activity of enzymes such as protein kinase C and NADPH oxidase.Spécification
BLVRA | |
Polyclonal | |
Unconjugated | |
BLVRA | |
Biliverdin IX alpha reductase, biliverdin reductase A, BLVR, BLVRA, BVR, BVR A, BVRA | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
109778, 644 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
0.43 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
P53004, Q9CY64 | |
BLVRA | |
BLVRA Fusion Protein Ag1166 | |
150 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |