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β-Catenin Mouse, Unlabeled, Clone: 14, BD
Mouse Monoclonal Antibody
212.93€ - 342.40€
Spécification
| Antigène | β-Catenin |
|---|---|
| Clone | 14 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
|---|---|---|---|---|---|---|---|---|---|
| Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
|
15815299
|
BD Biosciences
610153 |
50 μg |
 213.00€ 212.93€ / 1 kit Économisez 0.07€ 0.03% de réduction |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | |||||
|
15825299
|
BD Biosciences
610154 |
150 μg |
343.00€ 342.40€ / 1 kit Économisez 0.60€ 0.18% de réduction |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | |||||
Description
β-Catenin is a 92kDa protein that binds to the cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions (zonula adherens). Deletions in the cytoplasmic domain of E-Cadherin which eliminate catenin binding also result in a loss of cell adhesion, indicating that this binding is essential for E-Cadherin function. Although the α- and β-Catenins have been cloned, very little is known about their biochemical roles. However a link between β-Catenin and colon cancer has been described. β-Catenin was found to co-immunoprecipitate with the APC tumor suppressor protein in human colorectal tumor cell lines, as well as in human kidney 293 cells. E-Cadherin, however, was not detectable in these complexes. Thus the APC-Catenin complex may be affecting the transmission of contact inhibition signals and/or the regulation of cell adhesion.
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Spécification
| β-Catenin | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified |
| 14 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Canine, Chicken, Human, Mouse, Rat | |
| Mouse β-Catenin aa. 571-781 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
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