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CD180 Monoclonal Antibody (G28-8), Invitrogen™

Mouse Monoclonal Antibody

Marque:  Invitrogen MA110125

Code produit. 12322153

  • 422.00€ / 100µg

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Description

Description

CD180 (RP105, Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. CD180 cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1, and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size. CD180 consists of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is part of the cell surface receptor complex, RP105/MD-1. Diseases associated with CD180 dysfunction include Kawasaki Disease in children and may play a role in rheumatic disease pathology.
TRUSTED_SUSTAINABILITY
Spécification

Spécification

CD180
Monoclonal
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
Q99467
Cd180
Human tonsillar B cells
100 μg
Primary
Human
Antibody
IgG1 κ
Flow Cytometry, Immunoprecipitation
G28-8
Unconjugated
Cd180
CD180; CD180 antigen; CD180 molecule; F630107B15; LY64; Ly78; Ly-78; lymphocyte antigen 64; Lymphocyte antigen 78; lymphocyte antigen-64, radioprotective, 105kDa; MGC126233; MGC126234; radioprotective 105 kDa protein; RP105
Mouse
Protein A
RUO
4064
4° C, do not freeze
Liquid
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