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CD180 Monoclonal Antibody (G28-8), Invitrogen™
Mouse Monoclonal Antibody
Marque: Invitrogen MA110125
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Description
CD180 (RP105, Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. CD180 cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1, and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size. CD180 consists of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is part of the cell surface receptor complex, RP105/MD-1. Diseases associated with CD180 dysfunction include Kawasaki Disease in children and may play a role in rheumatic disease pathology.Spécification
CD180 | |
Monoclonal | |
1 mg/mL | |
PBS with 15mM sodium azide; pH 7.4 | |
Q99467 | |
Cd180 | |
Human tonsillar B cells | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 κ |
Flow Cytometry, Immunoprecipitation | |
G28-8 | |
Unconjugated | |
Cd180 | |
CD180; CD180 antigen; CD180 molecule; F630107B15; LY64; Ly78; Ly-78; lymphocyte antigen 64; Lymphocyte antigen 78; lymphocyte antigen-64, radioprotective, 105kDa; MGC126233; MGC126234; radioprotective 105 kDa protein; RP105 | |
Mouse | |
Protein A | |
RUO | |
4064 | |
4° C, do not freeze | |
Liquid |