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CD279 Mouse anti-Human, Unconjugated, Clone: EH12.2H7, Proteintech
Mouse Monoclonal Antibody
Marque: Proteintech 65168-1-IG-100UG
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Description
Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) (PMID: 18173375). PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines (PMID: 20636820). Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function (PMID: 19426218). It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity (PMID: 22658127; 23169436).
Spécification
| CD279 | |
| Monoclonal | |
| 1 mg/mL | |
| Mouse | |
| Primary | |
| Human, Mouse, Rat | |
| IgG1 κ |
| Flow Cytometry | |
| EH12.2H7 | |
| Unconjugated | |
| 100 μg | |
| 5133 | |
| Liquid |
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