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CD314 (NKG2D) Monoclonal Antibody (5C6), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Marque: Affymetrix eBioscience 14-5879-95
Description
The 5C6 MAb reacts with the human NKG2D, a 42 kDa lectin-like molecule expressed by NK cells, gammadelta T cells, some CD4^+ and CD8^+ T cells. Human NKG2D forms complexes with DAP10, a membrane adaptor protein, and has the ability to costimulate multiple NK activation receptors. The counter-receptor for human NKG2D has been identified as MICA/MICB expressed on epithelial tumors from lung, breast, kidney, ovary, prostate and colon carcinoma. 5C6 and 1D11 block binding of soluble MICA to gammadelta TCR T cell clones and inhibit lysis by these cells. 5C6 and 1D11 induced NKG2D function of redirected lysis of FcReceptor bearing P815 cells.
CD314 (NKG2D) Monoclonal antibody specifically detects CD314 (NKG2D) in Human samples. It is validated for Flow Cytometry, Functional Assay, Immunohistochemistry, Immunoprecipitation, Neutralization
Spécification
| CD314 (NKG2D) | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| P26718 | |
| Mouse | |
| 10 mg | |
| Primary | |
| Human | |
| Antibody | |
| IgG2a |
| Flow Cytometry, Functional Assay, Immunohistochemistry, Immunoprecipitation, Neutralization | |
| 5C6 | |
| Unconjugated | |
| Klrk1 | |
| CD314; D12S2489E; D6H12S2489E; killer cell lectin like receptor K1; Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K, member 1; KLR; Klrk1; natural killer cell group 2D; natural killer cell receptor; NK cell receptor D; NK lectin-like receptor; Nkg2d; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKLLR; Nkrp2; NKR-P2; NKR-P2, ortholog of human NKG2D | |
| Affinity chromatography | |
| RUO | |
| 22914 | |
| 4° C | |
| Liquid |
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