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CD324 (E-Cadherin) Monoclonal Antibody (DECMA-1), Functional Grade, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Marque: Affymetrix eBioscience 16-3249-025
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Description
The MAb DECMA-1 recognizes mouse, human and canine CD324 also known as E-cadherin (Epithelial cadherin) or uvomorulin. Like the other cadherin family members P and N cadherin, E-cadherin is a transmembrane glycoprotein involved in intercellular adhesion. These proteins share a common basic structure. The extracellular portions of the proteins are largely composed of repeating domains, each with two consensus Ca2+-binding motifs. The cytoplasmic domain interacts with a-, b-, and g-catenins and actinins. These catenins connect E-cadherin with the cytoskeleton. Expression is found in most epidermal cells including melanocytes and kerotinocytes. E-cadherin is localized at the intercellular boundaries of epithelial cells in several tissues, and is thought to play a role in maintenance of tissue integrity. Loss of E-cadherin function has been implicated in the progression of a variety of cancers. E-Cadherin protein is sensitive to trypsin treatment, so exposure to trypsin should be minimized or avoided. The MAb DECMA-1 has been shown to have functional activity by disrupting adhesion in human, mouse and dog cells.
CD324 (E-Cadherin) Monoclonal antibody specifically detects CD324 (E-Cadherin) in Canine, Human, Mouse samples. It is validated for Flow Cytometry, Functional Assay, Immunocytochemistry, Immunofluorescence, Neutralization
Spécification
| CD324 (E-Cadherin) | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with no preservative; pH 7.2 | |
| F1PAA9, P09803, P12830 | |
| Rat | |
| 25 mg | |
| Primary | |
| Canine, Human, Mouse | |
| Antibody | |
| IgG1 κ |
| Flow Cytometry, Functional Assay, Immunocytochemistry, Immunofluorescence, Neutralization | |
| DECMA-1 | |
| Functional Grade | |
| CDH1 | |
| AA960649; Arc-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; Cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-Cadherin phospho; Epithelial cadherin; hab; half baked; LCAM; L-CAM; phospho cadherin 1; phospho E-Cadherin; phospho LCAM; phospho S838; phospho UVO; S840; S840 E-Cadherin; Ser840; Ser840 E-Cadherin; Um; UVO; Uvomorulin | |
| Affinity chromatography | |
| RUO | |
| 12550, 442858, 999 | |
| 4° C | |
| Liquid |
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