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CD365 (TIM1) Monoclonal Antibody (1D12-TIM1), PE, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
175.00€ - 393.00€
Spécification
Antigène | CD365 (TIM1) |
---|---|
Clone | 1D12-TIM1 |
Concentration | 5 μL/Test |
Applications | Flow Cytometry |
Classification | Monoclonal |
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
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Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
16380604
|
Affymetrix eBioscience
12-3659-42 |
100 Tests |
393.00€
100 pièces |
Expédition estimée: 05-06-2024 Connectez-vous pour voir le stock disponible |
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16370604
|
Affymetrix eBioscience
12-3659-41 |
25 Tests |
Cet article est actuellement indisponible ou discontinu.
Veuillez consulter la page produit pour de possible alternative dans l’onglet |
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Description
Description: This 1D12-TIM1 monoclonal antibody recognizes human CD365 also known as Tim-1, Kim-1 or Havcr1. This antibody was generated using the immunoglobulin V domain of the extracellular part of the CD365 receptor, and is predicted to recognize all three haplotypes of human CD365. Clone 1D12-TIM1 has been shown to block entry of HCV virus into human hepatoma Huh7.5 cells in a dose dependent manner. It has been also shown to block the uptake of apoptotic cells by CD365-expressing 769-P cells. Applications Reported: This 1D12-TIM1 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 1D12-TIM1 antibody has been pre-diluted and tested by flow cytometric analysis of A549 cells. This may be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser
CD365 also known as T-cell immunoglobulin and mucin domain 1 (Tim-1) is a type 1 surface glycoprotein that consists of extracellular N-terminal immunoglobulin V-like domain and a mucin domain, and a short cytoplasmic tail. The endogenous ligand for CD365 is Tim-4. In addition, CD365 is known to be a cellular receptor or co-receptor for a number of viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus. The direct binding of the viruses by CD365 occurs via phosphatildyl-serine exposed on viral envelopes. Polymorphisms within human CD365 gene (HAVCR1) are associated with susceptibility to infection and the disease severity. CD365 has also been implicated in the T cell co-stimulation. CD365 is primarily expressed in epithelial cells. It is also highly expressed in A549, 769-P and Caco-2 and cell lines. CD365 exists also as a soluble protein generated by metalloproteinase mediated proteolytic cleavage of the surface protein.Spécification
CD365 (TIM1) | |
5 μL/Test | |
Monoclonal | |
Liquid | |
RUO | |
Q96D42 | |
Havcr1 | |
IgG1 κ | |
Affinity chromatography | |
Antibody |
1D12-TIM1 | |
Flow Cytometry | |
PE | |
Mouse | |
Human | |
26762 | |
IgV domain of human CD365 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
Havcr1 |