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CD49f (Integrin α6) Rat, anti-Mouse, Pacific Blue, Clone: GoH3, STEMCELL Technologies
Rat Monoclonal Antibody
Marque: Stemcell Technologies 60037PB.1
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Description
- The GoH3 antibody reacts with CD49f (integrin α6), an ∼150 kDa transmembrane glycoprotein that associates non-covalently with CD29 (integrin β1) or CD104 (integrin β4) to form the heterodimeric receptors VLA-6 and α6β4, which bind the extracellular matrix protein laminin
- CD49f is a disulfide-linked dimer comprising an ∼120 kDa heavy chain and an ∼30 kDa membrane-bound light chain
- Splice variants exist, which affect the cytoplasmic domain of the protein
- CD49f is expressed on the surface of T cells, monocytes, platelets, placental trophoblasts, epithelial cells, and endothelial cells
- It is involved in cell adhesion and regulating signaling pathways involved in a variety of processes, including the activation and proliferation of T cells, and the differentiation and maintenance of stem cell pluripotency
- CD49f is considered the most important marker for selecting mouse mammary stem and progenitor cells
- The GoH3 antibody reacts with an extracellular epitope on CD49f
Spécification
| CD49f (Integrin α6) | |
| Monoclonal | |
| Pacific Blue | |
| 25 Tests | |
| Baboon, Cynomolgus, Pig, Human | |
| Mammary Cells |
| Immunohistochemistry, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Functional Assay | |
| GoH3 | |
| Rat | |
| Primary | |
| IgG2a κ |
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