Invitrogen™ CLEC4E Monoclonal Antibody (WEN43)

Description

Product is supplied at 1 mL (100 μL/mL). Application notes: Flow Cytometry - This anitbody stains the extracellular domain of Mincle transfected 293 cells. It does not bind to other receptors in the rat APLEC family. Functional Assay - This antibody can act complementary in the inhibition of phagocytosis. Positive control: BW5417 or 293T cells.

CLEC4E encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.