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DLL1 (delta-like 1) Monoclonal Antibody (HMD1-5), Functional Grade, eBioscience™, Invitrogen™
Armenian Hamster Monoclonal Antibody
2985.00€ - 14910.00€
Spécification
| Antigène | DLL1 (delta-like 1) |
|---|---|
| Clone | HMD1-5 |
| Concentration | 1 mg/mL |
| Applications | Functional Assay |
| Classification | Monoclonal |
Description
The HMD1-5 MAb reacts with mouse Delta-like 1, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g. Notch 1-4), Delta-like 1 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases an intracellular fragment whose biological function remains controversial. Delta-like 1 is expressed by thymic stromal cells, as well as on macrophages, dendritic cells, and stromal cells in the spleen. This protein is also expressed in nonhematopoietic tissues such as the lung and brain. Delta-like 1 has been linked to B cell development and differentiation, especially marginal zone and plasma cells, regulation of splenic dendritic cells, and leukemogenesis. This MAb has been reported to have neutralizing activity.
DLL1 (delta-like 1) Monoclonal antibody specifically detects DLL1 (delta-like 1) in Mouse samples. It is validated for Functional AssaySpecifications
| DLL1 (delta-like 1) | |
| 1 mg/mL | |
| Monoclonal | |
| Liquid | |
| RUO | |
| PBS with no preservative; pH 7.2 | |
| C-Delta-1; Delta; delta like canonical Notch ligand 1; delta like-1; Delta1; delta-like 1; delta-like 1 (Drosophila); delta-like protein 1; DL1; Dll1; Dll1-derived cell-associated form; Dll1-EC; Dll1-IC; Dll1-intracellular form; Dll1-soluble form; Dll1-TMIC; Drosophila Delta homolog 1; H-Delta-1; OTTHUMP00000017690; UNQ146/PRO172 | |
| IgG | |
| Affinity chromatography | |
| Antibody |
| HMD1-5 | |
| Functional Assay | |
| Functional Grade | |
| Armenian Hamster | |
| Mouse | |
| Q61483 | |
| 13388 | |
| Primary | |
| 4° C | |
| DLL1 |
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