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Invitrogen™ EID1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marque: Invitrogen™ PA562323
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Description
Immunogen sequence: DEGEEFDDWE DDYDYPEEEQ LSGAGYRVSA ALEEADKMFL RTREPALDGG FQMHYEKTPF DQLAFIEELF SLMVVNRLTE ELGCDEI Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 80%.
E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator.
Spécification
| EID1 | |
| Polyclonal | |
| Unconjugated | |
| EID1 | |
| 21 kDa pRb-associated protein; 2610002K20Rik; C15orf3; CREBBP/EP300 inhibitor 1; CREBBP/EP300 inhibitory protein 1; CRI1; E1A-like inhibitor of differentiation 1; EID; eid1; EID-1; EP300 interacting inhibitor of differentiation 1; EP300-interacting inhibitor of differentiation 1; IRO45620; NB4 apoptosis related protein; ORF12; PNAS-22; PTD014; Rb- and p300-binding protein EID-1; RBP21; retinoblastoma protein-associated protein; RGD1562702 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 23741 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin) | |
| 0.1 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q9Y6B2 | |
| EID1 | |
| Recombinant protein corresponding to Human EID1. Recombinant protein control fragment (Product #RP-98153). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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