Invitrogen™ Epstein Barr Virus Bam H1 Z Early Antigen Monoclonal Antibody (B09C)

Description

The MA1-7276 antibody reacts with Epstein-Barr virus Bam H1 Z in viral and infected tissue samples. MA1-7276 has been successfully used in ELISA, Western blot, Immunohistochemical and Immunoprecipitation applications. The MA1-7276 antibody was raised against EBV Bam H1 Z early antigen.

Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.