Invitrogen™ GLUT1 Polyclonal Antibody

Description

PA1-1063 detects GLUT1 in rat, mouse and bovine samples. PA1-1063 has been successfully used in Western blot and immunofluorescence procedures. By Western blot, this antibody detects a ~42 kDa protein representing GLUT1 in rat, mouse and bovine brain samples. The PA1-1063 immunogen is a synthetic peptide corresponding to residues S(475) D K T P E E L F H P L G A D S Q V(492) of rat GLUT1. This sequence is conserved across many species including mouse, bovine, human, porcine and ovine. This peptide (Cat. # PEP-289) is available for use in neutralization and control experiments.

Glucose transporter 1 (GLUT1), encoded by the SLC2A1 gene, is a facilitative glucose transporter that plays a pivotal role in the uptake of glucose across cell membranes, particularly in tissues with high-energy demands such as the brain, erythrocytes, and endothelial cells of the blood-brain barrier. GLUT1 is ubiquitously expressed and functions through a passive diffusion mechanism, allowing glucose to move down its concentration gradient. Its involvement in maintaining glucose homeostasis is crucial for cellular metabolism and energy production. Mutations in SLC2A1 can lead to GLUT1 deficiency syndrome, characterized by seizures, developmental delay, and movement disorders due to impaired glucose transport into the brain. GLUT1 also plays a significant role in cancer biology, where its overexpression is commonly observed in various tumors, facilitating the enhanced glucose uptake required for rapid tumor cell proliferation. This characteristic makes GLUT1 a potential target for cancer diagnostics and therapeutics. Additionally, GLUT1's regulation is influenced by factors such as hypoxia, insulin, and cellular stress, highlighting its adaptive role in different physiological and pathological states.