Invitrogen™ HP1 beta Monoclonal Antibody (1MOD-1A9)

Description

MA3-053 detects HP1-beta in human samples. MA3-055 has been succesfully used in western blot, immunofluorescence, ELISA and ChIP applications. Immunogen is a HP1-beta recombinant mouse.

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.