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ACROBiosystems Human GITR Ligand / TNFSF18 Protein, Fc Tag

Marque:  ACROBiosystems GIL-H526A-1MG

Informations supplémentaires : Poids : 0.00001kg

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Code produit. 15846837

  • 3203.09€ / 1mg
Expédition estimée: 11-04-2024
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Description

Description

Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.

This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 41.5 kDa. The protein migrates as 45-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spécification

Spécification

AAH69319.1
1 mg
Gln 50 - Ser 177
TNFSF18,AITRL,TL6,hGITRL,GITR Ligand
Unconjugated
Fc Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>95% as determined by SDS-PAGE
41.5 kDa
Human GITR Ligand, Fc Tag (GIL-H526a) is expressed from human 293 cells (HEK293). It contains AA Gln 50 - Ser 177 (Accession # AAH69319.1).
-20°C
GITR Ligand
Human
50 mM Tris, 100 mM Glycine, pH7.5
HEK293
Immune Checkpoint Proteins
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