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ICAM-3 Monoclonal Antibody (MEM-171), PE, Invitrogen™

Mouse Monoclonal Antibody

Marque:  Invitrogen MA110244

Code produit. 12332263

  • 384.00€ / 100 pièces

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Description

Description

This antibody recognizes an epitope in the D2 domain of CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes.

CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.
TRUSTED_SUSTAINABILITY
Spécification

Spécification

ICAM-3
Monoclonal
PE
ICAM3
CD50; CDw50; ICAM3; ICAM-3; ICAM-R; Intercellular adhesion molecule 3; intercellular adhesion molecule-3
Mouse
Size-exclusion chromatography
RUO
3385
4° C, store in dark, DO NOT FREEZE!
Liquid
Flow Cytometry
MEM-171
PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
P32942
ICAM3
Human granulocytes
100 Tests
Primary
Human
Antibody
IgG1
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