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ICAM-3 Monoclonal Antibody (MEM-171), PE, Invitrogen™
Mouse Monoclonal Antibody
Marque: Invitrogen MA110244
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Description
This antibody recognizes an epitope in the D2 domain of CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes.
CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.Spécification
ICAM-3 | |
Monoclonal | |
PE | |
ICAM3 | |
CD50; CDw50; ICAM3; ICAM-3; ICAM-R; Intercellular adhesion molecule 3; intercellular adhesion molecule-3 | |
Mouse | |
Size-exclusion chromatography | |
RUO | |
3385 | |
4° C, store in dark, DO NOT FREEZE! | |
Liquid |
Flow Cytometry | |
MEM-171 | |
PBS with 0.2% BSA and 15mM sodium azide; pH 7.4 | |
P32942 | |
ICAM3 | |
Human granulocytes | |
100 Tests | |
Primary | |
Human | |
Antibody | |
IgG1 |