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IL-15/IL-15R Complex Monoclonal Antibody (GRW15PLZ), Functional Grade, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Marque: Affymetrix eBioscience 16-8156-050
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Description
The MAb GRW15PLZ recognizes the mouse IL-15/IL-15 receptor complex. Interleukin-15 (IL-15) is a 14 kDa proinflammatory protein that is has been shown to play a role in the activation of neutrophils, dendritic cells, and macrophages, and is essential to the development and survival of NK cells and CD8 T-cells. IL-15 activates Jak/Stat pathways by signaling through a heterotrimeric receptor. Two of the subunits of this receptor, beta and gamma, are shared with the IL-2 receptor, while the alpha subunit is unique to IL-15. Despite the expression of IL-15 mRNA in many cell types, the secreted protein is rarely detectable in biological samples. Recent research suggests that IL-15 is retained inside the cell and is only secreted when in complex with its unique receptor, IL-15R alpha. The cytokine/receptor complex may stay bound to the cell surface, where it can be trans-presented to cells expressing the beta gamma subunits of the receptor, or may be secreted in a soluble form that lacks the transmembrane domain of the receptor. The soluble IL-15/IL-15R complex is produced by mouse dendritic cells, fibroblasts, and macrophages and demonstrates a 10-100-fold increase in agonistic activity over IL-15 alone. The MAb GRW15PLZ reacts with and inhibits the bioactivity of IL-15 and the IL-15/IL-15R complex.
IL-15/IL-15R Complex Monoclonal antibody specifically detects IL-15/IL-15R Complex in Mouse samples. It is validated for Functional Assay, Neutralization
Spécification
| IL-15/IL-15R Complex | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with no preservative; pH 7.2 | |
| P48346, Q60819 | |
| Rat | |
| 50 mg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG1 κ |
| Functional Assay, Neutralization | |
| GRW15PLZ | |
| Functional Grade | |
| Il15ra | |
| AA690181; AI503618; CD215; Il15; IL-15; IL-15 receptor subunit alpha; Il15ra; IL-15RA; IL-15R-alpha; ILN; Interleukin; interleukin 15; interleukin 15 receptor, alpha chain; interleukin-15; Interleukin-15 receptor subunit alpha; sIL-15 receptor subunit alpha; Soluble interleukin-15 receptor subunit alpha | |
| Affinity chromatography | |
| RUO | |
| 16168, 16169 | |
| 4° C | |
| Liquid |
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