Invitrogen™ Influenza A NP Recombinant Rabbit Monoclonal Antibody (113)

Description

Widely recognize Influenza A Nucleoprotein. Has cross-reactivity in WB and ELISA with: H1N1 (A/Brevig Mission/1/1918) NP; H3N2 (A/Darwin/9/2021)/(A/Darwin/6/2021) NP Protein; H5N1 (A/Texas/37/2024) NP Protein. Has cross-reactivity in ELISA with: H1N1 (A/Brisbane/02/2018) NP; H1N1 (A/California/07/2009) NP; H1N1 (A/Guangdong-Maonan/SWL1536/2019) NP; H1N1 (A/Hawaii/70/2019) NP; H1N1 (A/Michigan/45/2015 NP; H1N1 (A/Puerto Rico/8/34/Mount Sinai) NP (I116M); H1N1 (A/Victoria/2454/2019) NP; H1N1 (A/Victoria/2570/2019)/(A/Wisconsin/588/2019) NP; H2N2 (A/Ann Arbor/6/1960) NP; H3N2 (A/Aichi/2/1968) NP; H3N2 (A/Cambodia/e0826360/2020 (H3N2)-like NP; H3N2 (A/Hong Kong/1/1968) NP; H3N2 (A/Hong Kong/2671/2019) NP; H3N2 (A/Hong Kong/45/2019) NP; H3N2 (A/Hong Kong/4801/2014) NP; H3N2 (A/Kansas/14/2017) NP; H3N2 (A/Switzerland/9715293/2013) NP; H7N9 (A/Anhui/1-BALF_RG6/2013) NP; H7N9 (A/Shanghai/2/2013) NP; Influenza B (B/Phuket/3073/2013) NP; Influenza B (B/Brisbane/60/2008) NP; Influenza B (B/Colorado/06/2017) NP; No cross-reactivity in WB and ELISA with: Influenza B (B/Austria/1359417/2021) NP Protein; Influenza B (B/Phuket/3073/2013) NP Protein; No cross-reactivity in ELISA with: Influenza B (B/Florida/4/2006) NP; Influenza B (B/Washington/02/2019) NP; SARS-CoV-2 Nucleocapsid Protein; HCoV-229E Nucleocapsid Protein HCoV-NL63 Nucleocapsid Protein; HCoV-HKU1 Nucleocapsid Protein; HCoV-OC43 Nucleocapsid Protein.

The nucleoprotein (NP) of Influenza A virus encapsidates the negative strand of the viral RNA and is essential for replicative transcription. It may also be involved in other essential functions throughout the virus life cycle. As well as binding ssRNA, NP is able to self associate to form large oligomeric complexes. NP is able to interact with a variety of other macromolecules of both viral and cellular origins. It binds the PB1 and PB2 subunits of the polymerase and the matrix protein M1. 'NP has also been shown to interact with at least four cellular polypeptide families: nuclear import receptors of the importin class, filamentous (F) actin, the nuclear export receptor CRM1 and a DEAD box helicase BAT1/UAP56' (Portela et al 2002).