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Invitrogen™ Lano Polyclonal Antibody
Rabbit Polyclonal Antibody
Marque: Invitrogen™ PA556792
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Description
Immunogen sequence: NERAVNRVSA IRFVEDEKDE EDNETRTLLR RATPHPGELK HMKKTVENLR NDMNAAKGLD SNKNEVNHAI DRVTT Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 84%.
Lano is a member of the LAP (leucine-rich repeats and PDZ) family of proteins that also includes Densin-180, Erbin, and hScribble. The LAP proteins generally contain multiple leucine-rich repeat (LRR) domains which serve to target them to the basolateral membrane of epithelial cells. Lano is unique in that it alone does not possess one or more PDZ (PSD95/DLG/ZO-1) domains as do the other members of the LAP family. However, it can bind to the PDZ domain of Erbin in addition to those of membrane-associated and guanylate kinase (MAGUK) proteins which regulate adhesion and plasticity at cell junctions. It has been suggested that it is through these interaction that these LAP proteins participate in the maintenance of proper embryonic development and integrity of epithelial tissues.
Spécification
| Lano | |
| Polyclonal | |
| Unconjugated | |
| LRRC1 | |
| A430093J20Rik; AU016091; D030059I21; dJ523E19.1; LANO; LANO adapter protein; LAP (leucine-rich repeats and PDZ) and no PDZ protein; LAP and no PDZ protein; leucine rich repeat containing 1; leucine-rich repeat-containing 1; leucine-rich repeat-containing protein 1; LRRC1; mKIAA4018; RP3-523E19.1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 367113, 55227 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 0.05 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q9BTT6 | |
| LRRC1 | |
| Recombinant protein corresponding to Human LRRC1. Recombinant protein control fragment (Product #RP-94870). | |
| 100 μL | |
| Primary | |
| Human, Rat | |
| Antibody | |
| IgG |
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