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Invitrogen™ MB67 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marque: Invitrogen™ PA529866
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Description
Recommended positive controls: mouse liver. Predicted reactivity: Rat (80%), Rhesus Monkey (96%), Chimpanzee (100%), Bovine (81%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists.
Spécification
| MB67 | |
| Polyclonal | |
| Unconjugated | |
| NR1I3 | |
| AA209988; AI551208; Car; CAR1; CAR-beta; Care2; constitutive activator of retinoid response; constitutive active receptor; constitutive active response; constitutive androstane nuclear receptor variant 2; constitutive androstane nuclear receptor variant 3; constitutive androstane nuclear receptor variant 4; constitutive androstane nuclear receptor variant 5; constitutive androstane receptor; constitutive androstane receptor NR1I3; constitutive androstane receptor protein variant 1; constitutive androstane receptor protein variant 2; constitutive androstane receptor protein variant 3; constitutive androstane receptor protein variant 4; constitutive androstane receptor protein variant 5; constitutively transactivates RAREs; ESTM32; MB67; MGC150433; MGC97144; MGC97209; NR1I3; nuclear receptor; nuclear receptor constitutive active receptor; nuclear receptor subfamily 1 group I member 3; nuclear receptor subfamily 1, group I, member 3; orphan nuclear hormone receptor; orphan nuclear receptor MB67; strain Fischer nuclear receptor (CAR); Unknown (protein for MGC:137128) | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 12355, 9970 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7 | |
| O35627, Q14994 | |
| NR1I3 | |
| Recombinant protein encompassing a sequence within the center region of human NR1I3. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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