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Invitrogen™ MMAF Monoclonal Antibody (A5G12)
Mouse Monoclonal Antibody
Marque: Invitrogen™ MA542537
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Description
Product has been tested in direct ELISA.
Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. It is part of the approved drug belantamab mafodotin in multiple myeloma and some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A. In International Nonproprietary Names for MMAF-antibody-conjugates, the name mafodotin refers to MMAF plus its attachment structure to the antibody. Monomethyl auristatin F is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. It is linked to an antibody with high affinity to structures on cancer cells, causing MMAF to accumulate in such cells. MMAF is actually desmethyl-auristatin F; that is, the N-terminal amino group has only one methyl substituent instead of two as in auristatin F itself.
Spécification
| MMAF | |
| Monoclonal | |
| 2 mg/mL | |
| PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4 | |
| Mouse | |
| Protein G | |
| RUO | |
| Chemical | |
| Antibody | |
| IgG1 |
| ELISA | |
| A5G12 | |
| Unconjugated | |
| Monomethyl auristatin F | |
| MMAF coupled with OVA. | |
| 100 μL | |
| Primary | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid | |
| Chemical |
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