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ABCC2, Mouse, Clone: M2II-12, Abnova™
Mouse monoclonal antibody raised against partial recombinant ABCC2.
Marque: Abnova MAB3383.500uL
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Description
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq
Spécification
| ABCC2 | |
| Monoclonal | |
| Unconjugated | |
| Western Blot (1:20-50) Immunohistochemistry (Frozen sections) (1:20) Immunocytochemistry (1:20-1:50) The optimal working dilution should be determined by the end user. | |
| ABCC2 | |
| ABCC2 | |
| Recombinant fusion protein corresponding to amino acids 860-950 of human ABCC2. | |
| RUO | |
| 1244 | |
| Human | |
| Liquid |
| Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot | |
| M2II-12 | |
| Mouse monoclonal antibody raised against partial recombinant ABCC2. | |
| In serum-free cell culture supernatant (0.09% sodium azide, 0.7% BSA) | |
| ABC30/CMOAT/DJS/KIAA1010/MRP2/cMRP | |
| Mouse | |
| 500 μL | |
| Primary | |
| Reacts with an internal epitope of human cMOAT/MRP2. Does not cross-react with human MDR1, MRP1, MRP3, and MRP5 gene products. | |
| Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. |
|
| IgG2a |
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