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Invitrogen™ NACA Polyclonal Antibody
Rabbit Polyclonal Antibody
Marque: Invitrogen™ PA5116506
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Description
Positive Samples: HL-60, SW620, 293T, U-87MG, HeLa, Mouse liver, Mouse kidney, Mouse brain, Rat brain Immunogen sequence: MPGEATETVP ATEQELPQPQ AETGSGTESD SDESVPELEE QDSTQATTQQ AQLAAAAEID EEPVSKAKQS RSEKKARKAM SKLGLRQVTG VTRVTIRKSK NILFVITKPD VYKSPASDTY IVFGEAKIED LSQQAQLAAA EKFKVQGEAV SNIQENTQTP TVQEESEEEE VDETGVEVKD IELVMSQANV SRAKAVRALK NNSNDIVNAI MELTM.
NACA prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). It binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. NACA also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites), and may act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.
Spécification
| NACA | |
| Polyclonal | |
| Unconjugated | |
| NACA | |
| AL022831; AL024382; Alpha-NAC; Alpha-NAC, muscle-specific form; alpha-NAC/1.9.2; Gm1878; Hom s 2; HSD48; mKIAA0363; NACA; NACA1; NAC-alpha; nascent polypeptide-associated complex alpha polypeptide; nascent polypeptide-associated complex alpha subunit; nascent polypeptide-associated complex subunit alpha; Nascent polypeptide-associated complex subunit alpha, muscle-specific form; nascent-polypeptide-associated complex alpha polypeptide; skNAC | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 17938, 288770, 4666 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ELISA, Western Blot, Western Blot | |
| 0.22 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| E9PAV3, P70670, Q13765, Q60817 | |
| NACA | |
| Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human NACA (NP_0011066731). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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