Invitrogen™ NGFR Monoclonal Antibody (MC192)

Description

Reconstitute in 100 μL of sterile water. Centrifuge to remove any insoluble material. The MC192 is supplied in lyophilised form from Protein G-purified hybridoma cell culture supernatants. The lyophilised antibody is stable when stored at 2-8 °C or -20 °C. After reconstitution undiluted aliquots should be kept at -20 °C for up to six months. For additional stability Glycerol (1:1) may be added after reconstitution. Repetitive freeze/thaw cycle should be avoided.

Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.