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PCNA Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marque: Invitrogen PA512449
337.35 EUR valable jusqu'au 2025-03-29
Utilisez le code promo "24111" pour bénéficier de cette offre.
Alert:
Pour que la promotion s’applique, le client doit acheter trois fois le même produit au prix catalogue sur la même commande pour avoir une remise de 33.33%. Il n’y a pas de limite d’achat pour un multiple de 3 produits. PCODE: 24111
Description
This antibody is predicted to react with bovine, chicken, hamster, mouse, non-human primate and rat based on sequence homology.
PCNA (polymerase delta auxiliary protein) is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumor tissue (i.e. relevant to prognosis). PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. PCNA is found in the nucleus and is a cofactor of DNA polymerase delta, and acts as a homotrimer and helps increase the processing of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of PCNA have been described on chromosome 4 and on the X chromosome.
Spécification
| PCNA | |
| Polyclonal | |
| Unconjugated | |
| Pcna | |
| ATLD2; cb16; Cyclin; DNA polymerase delta auxiliary protein; etID36690.10; fa28e03; fb36g03; HGCN8729; hypothetical protein LOC515499; MGC8367; Pcna; pcna protein; Pcna/cyclin; PCNAR; POL30; Proliferating cell nuclear antigen; wu:fa28e03; wu:fb36g03; YBR0811; YBR088C | |
| Rabbit | |
| Ammonium sulfate precipitation, Size-exclusion - Dialysis | |
| RUO | |
| 5111 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
| 2 mg/mL | |
| PBS with 0.09% sodium azide | |
| P12004 | |
| Pcna | |
| KLH conjugated synthetic peptide between 89-117 amino acids from the central region of human PCNA | |
| 400 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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