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Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8), Invitrogen™

Mouse Monoclonal Antibody

Marque:  Invitrogen MN1020

619.57 EUR valable jusqu'au 2024-12-31
Utilisez le code promo "21882" pour bénéficier de cette offre.

Code nomenclature Nacres: NA.41

Informations supplémentaires : CAS : 132546-81-7 Poids : 0.61240kg

Code produit. 10599853

  • 686.00€ / 100µg
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MN1020 recognizes a phosphatase-senstive epitope on PHF-Tau. No cross reactivity with normal Tau has been observed. The epitope of this antibody contains the phosphorylated Ser202 (4,5) residue (numbering according to human Tau40). MN1020 detects PHF-tau (Ser202/Thr205)a which has a predicted molecular weight of approximately 79 kDa. This product is a Low Endotoxin formulation. Purity is >95% as determined by SDS-PAGE.

Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, μgtimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.


Phospho-Tau (Ser202, Thr205)
0.2 mg/mL
100 μg d‘anticorps purifié provenant de surnageant de culture sans sérum par chromatographie d‘affinité de la protéine A ; sans conservateur ni protéine porteuse dans du PBS.
P10636, P10637
Partially purified human PHF-Tau
100 μg
Human, Mouse
IgG1 κ
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
AI413597; AW045860; DDPAC; FLJ31424; FTDP17; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; map tau; Mapt; MAPTL; MGC138549; microtubule associated protein tau; microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; microtubules; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; neurofibrillary tangles; Neuronal Marker; paired helical filament-tau; PHFtau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; pTau; RNPTAU; Tau; Tau microtubule-associated protein; tau protein; Tau-4; Tau5; Unknown (protein for MGC:134287)
Protein A
17762, 4137
-20° C, Avoid Freeze/Thaw Cycles
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