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Invitrogen™ PR3 Monoclonal Antibody (PR3G-2)
Mouse Monoclonal Antibody
Marque: Invitrogen™ MA140218
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Description
MA1-40218 detects Proteinase 3 from human samples. MA1-40218 has been successfully used in ELISA, flow cytometry, immunohistochemistry (frozen), and Western blot applications. The MA1-40218 immunogen is human PR3. Endotoxin <24 EU/mg.
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). [UniProt].
Spécification
| PR3 | |
| Monoclonal | |
| 0.1 mg/mL | |
| PBS with 0.1% BSA and no preservative | |
| P24158 | |
| PRTN3 | |
| Crude alpha granule extract. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Western Blot | |
| PR3G-2 | |
| Unconjugated | |
| PRTN3 | |
| ACPA; AGP7; azurophil granule protein 7; CANCA; C-ANCA; C-ANCA antigen; leukocyte proteinase 3; MBN; MBT; mPR3; Myeloblastin; neutrophil proteinase 4; NP4; NP-4; P29; PR3; PR-3; Proteinase 3; PRTN3; serine proteinase, neutrophil; wegener autoantigen; Wegener granulomatosis autoantigen | |
| Mouse | |
| Protein G | |
| RUO | |
| 5657 | |
| 4°C | |
| Liquid |
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