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Invitrogen™ RBM25 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marque: Invitrogen™ PA567122
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Description
Immunogen sequence: FPPPVPPGTPM IPVPMSIMAP APTVLVPTVS MVGKHLGARK DHPGLKAKEN DENCGPTTTV FVGNISEKAS DMLIRQLLAK CGLVLSW Highest antigen sequence identity to the following orthologs - mouse 99%, rat 99%.
RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.
Spécification
| RBM25 | |
| Polyclonal | |
| Unconjugated | |
| RBM25 | |
| 2600011C06Rik; 2610015J01Rik; A130095G20Rik; AI159652; AL023075; arg/Glu/Asp-rich protein of 120 kDa; Arg/Glu/Asp-rich protein, 120 kDa; AU043498; fSAP94; functional spliceosome-associated protein 94; LOC540258 protein; NET52; Protein S164; Rbm25; RED120; RNA binding motif protein 25; rna-binding; RNA-binding motif protein 25; RNA-binding protein 25; RNA-binding protein 25-like protein; RNA-binding region (RNP1, RRM) containing 7; RNA-binding region-containing protein 7; RNPC7; S164; Snu71; U1 small nuclear ribonucleoprotein 1SNRP homolog | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 58517 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry | |
| 0.05 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| P49756 | |
| RBM25 | |
| Recombinant Human RBM25. Recombinant protein control fragment (Product #RP-107768). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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