Invitrogen™ RDBP Polyclonal Antibody

Description

Immunogen sequence: LLALKKQSSS STTSQGGVKR SLSEQPVMDT ATATEQAKQL VKSGAISAIK AETKNSGFKR SRTLEGKLKD PEKGPVPTFQ PFQRSISADD DLQESSRRPQ RKSLYESFVS SSDRLRELGP DG Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 94%.

RDBP is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.