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RTF1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marque: Proteintech 12170-1-AP-150UL
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Description
Three isoforms of serine/threonine kinases, designated alphaPAK p68, betaPAK p65 and gammaPAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiae kinase Ste 20, involved in pheromone signaling. The alpha, beta and gammaPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. There are eight sites of autophosphorylation on gammaPAK, including Ser 19, Ser 141 and Thr 402, and phosphorylation of Ser 141 and Thr 402 is correlated with gammaPAK activation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates.Spécification
| RTF1 | |
| Polyclonal | |
| Unconjugated | |
| RTF1 | |
| CDG1N, GTL7, KIAA0252, RTF1 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 23168, 366169, 76246 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
| 0.4 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| A2AQ19, Q92541 | |
| Rtf1 | |
| RTF1 Fusion Protein Ag2812 | |
| 150 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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