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Invitrogen™ SUV420H2 Recombinant Human Monoclonal Antibody (RAB-C409)
Human Recombinant Monoclonal Antibody
Marque: Invitrogen™ MA551841
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Description
This antibody recognizes KMT5C (Histone-lysine N-methyltransferase KMT5C). It binds to a folded domain, amino acids 2-248. KMT5C is a histone methyltransferase that regulates transcription and maintenance of genome integrity.
SUV420H2 is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).
Spécification
| SUV420H2 | |
| Recombinant Monoclonal | |
| 1 mg/mL | |
| PBS with 0.02% ProClin 300 | |
| Q86Y97 | |
| KMT5C | |
| This antibody was obtained by recombinant antibody (rAb) phage display recognizing SUV420H2 protein under non-denaturing conditions. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| F(ab) κ |
| ChIP Assay, ELISA, Mass Spectrometry | |
| RAB-C409 | |
| Unconjugated | |
| KMT5C | |
| BC024816; Histone-lysine N-methyltransferase KMT5C; histone-lysine N-methyltransferase SUV420H2; KMT5C; lysine (K)-specific methyltransferase 5C; lysine methyltransferase 5C; lysine N-methyltransferase 5C; Lysine-specific methyltransferase 5C; PP7130; Su(var)4-20 homolog 2; suppressor of variegation 4-20 homolog 2; suppressor of variegation 4-20 homolog 2 (Drosophila); SUV420H2; suv4-20h2 | |
| Human | |
| Metal-chelate chromatography | |
| RUO | |
| 84787 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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