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Invitrogen™ TEK (TIE2) Y897S Recombinant Human Protein

This TEK (TIE2) Y897S Recombinant Human Protein (771-end) was expressed in insect cells.

Marque:  Invitrogen™ A30519

Informations supplémentaires : Poids : 0.10000kg

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Code produit. 15920293

  • 467.00€ / 10µg
Expédition estimée: 13-06-2022
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Description

Description

  • This TEK (TIE2) Y897S recombinant human protein (771–end) was expressed in insect cells
  • TEK (TIE2) Y897S receptor tyrosine kinase is expressed principally on vascular endothelium
  • Disrupting TEK Y897S function in mice results in embryonic lethality with defects in embryonic vasculature, suggesting a role in blood vessel maturation and maintenance
  • Angiopoietin-1 is a secreted growth factor that binds to and activates the TEK receptor tyrosine kinase
  • SHP2 and GRB2 are recruited to the activated TEK kinase domain, and are part of the cellular responses that mediate TEK function
  • TEK expression is upregulated in the endothelium of vascular 'hot spots' in human breast cancer specimens
  • However, TEK is also overexpressed in areas of active angiogenesis in normal tissues
  • TEK (TIE2) Y897S recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service
  • Validated for use with the Z'-LYTE™ assay
  • Available in multiple pack sizes for convenient use
Spécification

Spécification

NP_000450
10 µg
aa 771 - end
GST Tag
Insect
Liquid
Human
66.7 kDa
TIE Kinase Family
Yes
Dry Ice
Recombinant, Active, Catalytic
Kinase Assay
Vidéos
FDS
Documents
Certificats
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