Invitrogen™ TEK (TIE2) Y897S Recombinant Human Protein

This TEK (TIE2) Y897S Recombinant Human Protein (771-end) was expressed in insect cells.

Marque: Invitrogen™ A30519

Informations supplémentaires : Poids : 0.10000kg

Code produit. 15920293

Expédition estimée: 13-06-2022
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Description

This TEK (TIE2) Y897S recombinant human protein (771–end) was expressed in insect cells
TEK (TIE2) Y897S receptor tyrosine kinase is expressed principally on vascular endothelium
Disrupting TEK Y897S function in mice results in embryonic lethality with defects in embryonic vasculature, suggesting a role in blood vessel maturation and maintenance
Angiopoietin-1 is a secreted growth factor that binds to and activates the TEK receptor tyrosine kinase
SHP2 and GRB2 are recruited to the activated TEK kinase domain, and are part of the cellular responses that mediate TEK function
TEK expression is upregulated in the endothelium of vascular 'hot spots' in human breast cancer specimens
However, TEK is also overexpressed in areas of active angiogenesis in normal tissues
TEK (TIE2) Y897S recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service
Validated for use with the Z'-LYTE™ assay
Available in multiple pack sizes for convenient use

Spécification

Poids moléculaire	66.7 kDa
Famille des kinases	TIE Kinase Family
Recombinant	Yes
Conditions d’expédition	Dry Ice
Forme protéique	Recombinant, Active, Catalytic
Application validée	Kinase Assay

Description