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TH Mouse anti-Human, Mouse, Rat, Clone: 2H7B7, Proteintech

Mouse Monoclonal Antibody

Marque:  Proteintech 66334-1-IG-150UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16828115

  • 325.38€ / 150µL
Expédition estimée: 29-09-2022
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Description

Description

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson′s disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.
Spécification

Spécification

TH
Monoclonal
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P04177, P07101, P24529
TH
TH Fusion Protein Ag23075
150 μL
Primary
Rat, Mouse, Human
Antibody
IgG1
Western Blot, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry
2H7B7
Unconjugated
TH
TH, TYH, Tyrosine 3 hydroxylase, Tyrosine 3 monooxygenase, tyrosine hydroxylase
Mouse
Protein G
RUO
21823, 25085, 7054
-20°C
Liquid
Vidéos
FDS
Documents
Certificats
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