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Invitrogen™ Trastuzumab Recombinant Human Monoclonal Antibody (4D5-8 (trastuzumab))
Human Recombinant Monoclonal Antibody
Marque: Invitrogen™ MA547754
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Description
Specificity: Oncogenic protein Her-2/neu (erbB-2), a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30% of invasive breast cancers and 70% of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies originating from various organs, including ovary, kidney, colon, and bladder.
Trastuzumab with the brand name Herceptin, is an FDA-approved drug for HER2-targeted therapy for breast cancer. It is a recombinant humanized monoclonal antibody (IgG1 kappa). Trastuzumab binds to HER2 receptor present on the surface of HER2-positive tumour cells and suppresses the cells growth and proliferation.
Spécification
| Trastuzumab | |
| Recombinant Monoclonal | |
| 1 mg/mL | |
| PBS with 0.02% ProClin 300 | |
| Human | |
| Protein A | |
| RUO | |
| Human | |
| Antibody | |
| IgG1 κ |
| ELISA, Flow Cytometry, Immunohistochemistry | |
| 4D5-8 (trastuzumab) | |
| Unconjugated | |
| Herceptin | |
| A431 cells (human epidermoid carcinoma) (over)expressing EGFR. | |
| 200 μg | |
| Primary | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid | |
| Chemical |
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