Invitrogen™ Ubiquilin 1 Polyclonal Antibody

Description

PA1-759 detects ubiquilin from hamster cells. PA1-759 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~63 kDa protein representing ubiquilin from CHO cell extract. PA1-759 immunizing peptide corresponds to amino acids residues 2-18 from mouse ubiquilin.

PLIC1 is an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease.